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020			_z1845934075 (alk. paper)
020			_z9781845934071 (alk. paper)
040			_aCtWfDGI _beng _erda _cCtWfDGI
050	1	4	_aQP572.P4 _b.P47 2009eb
082	0	4	_a612.4/05 _223
245	0	0	_aPeptides in energy balance and obesity / _cedited by Gema Frühbeck, Department of Endocrinology, Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra and CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
246	1	4	_aPeptides in energy balance & obesity
264		1	_aWallingford, Oxfordshire, UK : _bCABI, _c2009.
264		4	_c©2009
300			_a1 online resource (xii, 389 pages) : _billustrations, charts.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
520	3		_aThe aim of this book is to provide an updated, detailed and comprehensive account of the field through a cutting-edge analysis by leading experts in the area. To achieve this, the book is divided into three parts, focusing on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part I contains three chapters covering the central pathways involved in the control of food intake. The first of these is devoted to the orexigenic neuropeptides, i.e. those that increase or stimulate appetite, while the second is a description of the peptides with anorexigenic effects, i.e. those that decrease or stop food intake. Since this is a rapidly evolving field, the third chapter concentrates on emerging and newly identified factors and their interaction with the already well-known peptides. Part II encompasses six chapters that deal with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. The underlying molecular mechanisms by which adipose tissue enlargement and the subsequent increase in adipokines contribute to the pathophysiological events in the gastrointestinal, hepatic, pancreatic, musculoskeletal, cardiovascular and immune systems are now beginning to be better understood and are covered in detail in this section of the book. Part III contains six chapters providing an integrative approach to current knowledge in energy balance regulation. Adipose tissue biology and the hierarchy of the neural circuitry controlling energy homeostasis deserve special attention, as does the relevance of food reward signals and the links between the homeostatic and hedonic systems. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management.
490	1		_aFrontiers in nutritional science ; _vno. 4
504			_aIncludes bibliographical references and index.
505	0		_aOrexigenic peptides / M.J. Morris and M.J. Hansen -- Anorexigenic peptides / S. Perboni, N. Ueno, G. Mantovani and A. Inui -- Newcomers and supporting actors / J.A. Harrold and G. Williams -- The gut as a second brain / C.J. Small, K. Wynne, and S.R. Bloom -- Elements of the adipostat / H. Hauner -- Natriuretic peptides and other lipolytic peptides involved in the control of lipid mobilization in humans / M. Lafontan, C. Sengenes, C. Moro, J. Galitzky and M. Berlan -- The adipo-hepato-insular axis in glucose homeostasis / J. Gómez-Ambrosi, V. Catalán, and G. Frühbeck -- Adipokines in the immune-stress response / R. Madani, N.C. Ogston, and V. Mohamed-Ali -- Peptides involved in vascular homeostasis / A. Rodríguez and G. Frühbeck -- Hierarchy of neural pathways controlling energy homeostasis / A. Abizaid and T.L. Horvath -- Energy regulatory signals and food reward / D. Figlewicz Lattemann, N.M. Sanders, and A.J. Sipols -- Embracing complexity : the emergence of functional neuroimaging and other methodologies to study the role of the human brain in the pathophysiology of obesity / P.A. Tataranni, N. Pannacciulli, D.S.NT Le and A. Del Parigi -- Overview of the integrative physiology of adipose tissue in energy homeostasis / I. Dugail and M. Guerre-Millo -- Application of 'OMIC' strategies to obesity research / C. Henegar, S. Taleb, D. Langin, J.-D. Zucker and K. Clément -- Implications for the future of obesity management / G.N. Chaldakov, A.B. Tonchev, M. Fiore, M.G. Hristova, R. Pancheva, G. Rancic and L. Aloe.
506			_aAccess limited to subscribing institution.
530			_aAlso available in print format.
588			_aTitle from PDF title page (viewed August 13, 2013).
650		0	_aObesity _xPathophysiology.
650	1	2	_aPeptides _xmetabolism.
650	2	2	_aEnergy Metabolism _xphysiology.
650	2	2	_aObesity _xphysiopathology.
650		0	_aEnergy metabolism.
650	2	2	_aHomeostasis.
650	2	2	_aAppetite Regulation.
650		0	_aPeptide hormones.
650		4	_aPhysiology of Human Nutrition.
650		4	_aNutrition related Disorders and Therapeutic Nutrition.
650		7	_aMan. _2cabt
650		7	_aAdipose tissue. _2cabt
650		7	_aAnorexiants. _2cabt
650		7	_aAppetite. _2cabt
650		7	_aBody weight. _2cabt
650		7	_aCardiovascular system. _2cabt
650		7	_aDigestive system. _2cabt
650		7	_aEnergy. _2cabt
650		7	_aEnergy balance. _2cabt
650		7	_aEnergy expenditure. _2cabt
650		7	_aFood intake. _2cabt
650		7	_aHomeostasis. _2cabt
650		7	_aHypothalamus. _2cabt
650		7	_aImmune system. _2cabt
650		7	_aLiver. _2cabt
650		7	_aMusculoskeletal system. _2cabt
650		7	_aNeuropeptides. _2cabt
650		7	_aObesity. _2cabt
650		7	_aPancreas. _2cabt
650		7	_aPeptides. _2cabt
650		7	_aPhysiopathology. _2cabt
650		7	_aRegulation. _2cabt
650		7	_aTherapy. _2cabt
650		7	_aVascular system. _2cabt
655		0	_aElectronic books.
690			_aVV120
690			_aVV130
700	1		_aFrühbeck, Gema, _eeditor of compilation.
710	2		_aC.A.B. International, _eissuing body.
710	2		_aNutrition Society (Great Britain)
776	0	8	_iPrint version: _tPeptides in energy balance and obesity. _dWallingford, Oxfordshire ; Cambridge, MA : CABI Pub. in association with the Nutrition Society, c2009. _z1845934075 _w(DLC)2008037565
830		0	_aFrontiers in nutritional science ; _vno. 4.
856	4	0	_uhttps://dx.doi.org/10.1079/9781845934071.0000 _zClick here to access resource
942			_cEB
999			_c313197 _d313197