000 | 06246cam a2200745 i 4500 | ||
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001 | on1048055848 | ||
003 | OCoLC | ||
005 | 20200810124438.0 | ||
006 | m o d | ||
007 | cr ||||||||||| | ||
008 | 180804s2019 nju ob 001 0 eng | ||
010 | _a 2018037472 | ||
040 |
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019 | _a1079363250 | ||
020 |
_a9781119378280 _q(Adobe PDF) |
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020 |
_a1119378281 _q(Adobe PDF) |
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020 |
_a9781119378303 _q(ePub) |
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020 |
_a1119378303 _q(ePub) |
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020 |
_z9781118361986 _q(hardback) |
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020 |
_a9781119378341 _q(electronic bk.) |
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020 |
_a1119378346 _q(electronic bk.) |
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_aCHNEW _b001030741 |
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035 |
_a(OCoLC)1048055848 _z(OCoLC)1079363250 |
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042 | _apcc | ||
050 | 1 | 0 |
_aRM301.25 _b.B56 2019 |
060 | 1 | 0 |
_aQV 241 _b.B615 2019 |
072 | 7 |
_aMED _x071000 _2bisacsh |
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082 | 0 | 0 |
_a615.1/9 _223 |
049 | _aMAIN | ||
245 | 0 | 0 |
_aBioprocessing technology for production of biopharmaceuticals and bioproducts / _cedited by Claire Komives, Weichang Zhou. |
250 | _aFirst edition. | ||
264 | 1 |
_aHoboken, NJ : _bJohn Wiley & Sons, Inc., _c2019. |
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300 | _a1 online resource (xiii, 273). | ||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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490 | 1 | _aWiley series in biotechnology and bioengineering | |
504 | _aIncludes bibliographical references and index. | ||
520 | _a"Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries Includes illustrative case studies that review six milestone bio-products Discusses a wide selection of host strain types and disruptive bioprocess technologies"--Provided by publisher. | ||
588 | 0 | _aPrint version record and CIP data provided by publisher; resource not viewed. | |
505 | 0 | _aCover; Title Page; Copyright; Contents; List of Contributors; Part I Case Study; Chapter 1 Bacillus and the Story of Protein Secretion and Production; 1.1 Bacillus as a Production Host: Introduction and Historical Account; 1.2 The Building of a Production Strain: Genetic Tools for B. subtilis Manipulation; 1.2.1 Promoters; 1.2.2 Vectors for Building a Production Strain; 1.2.3 B. subtilis Competent Cell Transformation; 1.2.4 Protoplasts-Mediated Manipulations; 1.2.5 Genetics by Electroporation; 1.3 B. subtilis Secretion System and Heterologous Protein Production | |
505 | 8 | _a1.3.1 Bacillus Fermentation and Recovery of Industrial Enzyme1.3.2 Fermentation Stoichiometry; 1.3.3 Fermentor Kinetics and Outputs; 1.3.4 Downstream Processing; 1.4 Summary; References; Chapter 2 New Expression Systems for GPCRs; 2.1 Introduction; 2.2 Recombinant GPCR Production -- Traditional Approaches for Achieving High-Level Production; 2.3 Engineered Expression Systems for GPCR Production; 2.3.1 Bacteria; 2.3.2 Yeasts; 2.3.3 Insect Cells; 2.3.4 Mammalian Cells; 2.3.5 Transgenic Animals; 2.3.6 Cell-Free Systems; 2.4 Conclusion; References; Chapter 3 Glycosylation; 3.1 Introduction | |
505 | 8 | _a3.2 Types of Glycosylation3.2.1 N-linked Glycans; 3.2.2 O-linked Glycans; 3.3 Factors Affecting Glycosylation; 3.3.1 Nutrient Depletion; 3.3.2 Fed-batch Cultures and Supplements; 3.3.3 Specific Culture Supplements; 3.3.4 Ammonia; 3.3.5 pH; 3.3.6 Oxygen; 3.3.7 Host Cell Systems; 3.3.8 Other Factors; 3.4 Modification of Glycosylation; 3.4.1 siRNA and Gene Knockout/Knockin; 3.4.2 Glycoprotein Processing Inhibitors and In Vitro Modification of Glycans; 3.5 Glycosylation Analysis; 3.5.1 Release of Glycans from Glycoproteins; 3.5.2 Derivatization of Glycans; 3.6 Methods of Analysis | |
505 | 8 | _a3.6.1 Lectin Arrays3.6.2 Liquid Chromatography; 3.6.2.1 HILIC Analysis; 3.6.2.2 Reversed Phase (RP) and Porous Graphitic Carbon (PGC) Chromatography; 3.6.2.3 Weak Anion Exchange (WAX) HPLC Analysis; 3.6.2.4 High pH Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD); 3.6.3 Capillary Electrophoresis (CE); 3.6.4 Fluorophore-assisted Carbohydrate Electrophoresis (FACE) and CGE-LIF; 3.6.5 Mass Spectrometry (MS); 3.6.5.1 Ionization; 3.6.5.2 Derivatization Techniques Used for MS Analysis of Glycans; 3.6.5.3 Fragmentation of Carbohydrates; 3.7 Conclusion; References | |
505 | 8 | _aPart II BioreactorsChapter 4 Bioreactors for Stem Cell and Mammalian Cell Cultivation; 4.1 Overview of (Mammalian and Stem) Cell Culture Engineering; 4.1.1 Cell Products for Therapeutics; 4.1.2 Cell as a Product: Stem Cells; 4.2 Bioprocess Characterization; 4.2.1 Cell Cultivation Methods; 4.2.2 Cell Metabolism; 4.2.3 Culture Medium Design; 4.2.4 Culture Parameters; 4.2.5 Culture Modes; 4.3 Cell Culture Systems; 4.3.1 Static Culture Systems; 4.3.2 Roller Bottles; 4.3.3 Spinner Flask; 4.3.4 Airlift Bioreactor; 4.3.5 Fixed/Fluidized-Bed Bioreactor; 4.3.6 Wave Bioreactor | |
650 | 7 |
_aMEDICAL / Pharmacology. _2bisacsh |
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650 | 0 | _aPharmaceutical biotechnology industry. | |
650 | 0 | _aBiotechnological process monitoring. | |
650 | 7 |
_aBiotechnological process monitoring. _2fast _0(OCoLC)fst00832727 |
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650 | 7 |
_aPharmaceutical biotechnology industry. _2fast _0(OCoLC)fst01060113 |
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650 | 1 | 2 |
_aBiological Products _xchemistry. |
650 | 2 | 2 | _aDrug Compounding. |
650 | 2 | 2 | _aTechnology, Pharmaceutical. |
650 | 2 | 2 | _aBioreactors. |
655 | 4 | _aElectronic books. | |
700 | 1 |
_aKomives, Claire, _eeditor. |
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700 | 1 |
_aZhou, Weichang, _d1963- _eeditor. |
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776 | 0 | 8 |
_iPrint version: _tBioprocessing technology for production of biopharmaceuticals and bioproducts. _bFirst edition. _dHoboken, NJ : John Wiley & Sons, Inc., 2018 _z9781118361986 _w(DLC) 2018036496 |
830 | 0 | _aWiley series in biotechnology and bioengineering. | |
856 | 4 | 0 |
_uhttps://doi.org/10.1002/9781119378341 _zWiley Online Library |
994 |
_aC0 _bDG1 |
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942 | _cEB | ||
999 |
_c311684 _d311684 |