000 06246cam a2200745 i 4500
001 on1048055848
003 OCoLC
005 20200810124438.0
006 m o d
007 cr |||||||||||
008 180804s2019 nju ob 001 0 eng
010 _a 2018037472
040 _aDLC
_beng
_erda
_cDLC
_dOCLCO
_dOCLCQ
_dOCLCA
_dEBLCP
_dN$T
_dDG1
_dSTF
_dOCLCO
_dCHVBK
_dOCLCF
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019 _a1079363250
020 _a9781119378280
_q(Adobe PDF)
020 _a1119378281
_q(Adobe PDF)
020 _a9781119378303
_q(ePub)
020 _a1119378303
_q(ePub)
020 _z9781118361986
_q(hardback)
020 _a9781119378341
_q(electronic bk.)
020 _a1119378346
_q(electronic bk.)
029 1 _aCHNEW
_b001030741
029 1 _aCHVBK
_b551943491
029 1 _aAU@
_b000063820645
029 1 _aGBVCP
_b1048686868
035 _a(OCoLC)1048055848
_z(OCoLC)1079363250
042 _apcc
050 1 0 _aRM301.25
_b.B56 2019
060 1 0 _aQV 241
_b.B615 2019
072 7 _aMED
_x071000
_2bisacsh
082 0 0 _a615.1/9
_223
049 _aMAIN
245 0 0 _aBioprocessing technology for production of biopharmaceuticals and bioproducts /
_cedited by Claire Komives, Weichang Zhou.
250 _aFirst edition.
264 1 _aHoboken, NJ :
_bJohn Wiley & Sons, Inc.,
_c2019.
300 _a1 online resource (xiii, 273).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aWiley series in biotechnology and bioengineering
504 _aIncludes bibliographical references and index.
520 _a"Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries Includes illustrative case studies that review six milestone bio-products Discusses a wide selection of host strain types and disruptive bioprocess technologies"--Provided by publisher.
588 0 _aPrint version record and CIP data provided by publisher; resource not viewed.
505 0 _aCover; Title Page; Copyright; Contents; List of Contributors; Part I Case Study; Chapter 1 Bacillus and the Story of Protein Secretion and Production; 1.1 Bacillus as a Production Host: Introduction and Historical Account; 1.2 The Building of a Production Strain: Genetic Tools for B. subtilis Manipulation; 1.2.1 Promoters; 1.2.2 Vectors for Building a Production Strain; 1.2.3 B. subtilis Competent Cell Transformation; 1.2.4 Protoplasts-Mediated Manipulations; 1.2.5 Genetics by Electroporation; 1.3 B. subtilis Secretion System and Heterologous Protein Production
505 8 _a1.3.1 Bacillus Fermentation and Recovery of Industrial Enzyme1.3.2 Fermentation Stoichiometry; 1.3.3 Fermentor Kinetics and Outputs; 1.3.4 Downstream Processing; 1.4 Summary; References; Chapter 2 New Expression Systems for GPCRs; 2.1 Introduction; 2.2 Recombinant GPCR Production -- Traditional Approaches for Achieving High-Level Production; 2.3 Engineered Expression Systems for GPCR Production; 2.3.1 Bacteria; 2.3.2 Yeasts; 2.3.3 Insect Cells; 2.3.4 Mammalian Cells; 2.3.5 Transgenic Animals; 2.3.6 Cell-Free Systems; 2.4 Conclusion; References; Chapter 3 Glycosylation; 3.1 Introduction
505 8 _a3.2 Types of Glycosylation3.2.1 N-linked Glycans; 3.2.2 O-linked Glycans; 3.3 Factors Affecting Glycosylation; 3.3.1 Nutrient Depletion; 3.3.2 Fed-batch Cultures and Supplements; 3.3.3 Specific Culture Supplements; 3.3.4 Ammonia; 3.3.5 pH; 3.3.6 Oxygen; 3.3.7 Host Cell Systems; 3.3.8 Other Factors; 3.4 Modification of Glycosylation; 3.4.1 siRNA and Gene Knockout/Knockin; 3.4.2 Glycoprotein Processing Inhibitors and In Vitro Modification of Glycans; 3.5 Glycosylation Analysis; 3.5.1 Release of Glycans from Glycoproteins; 3.5.2 Derivatization of Glycans; 3.6 Methods of Analysis
505 8 _a3.6.1 Lectin Arrays3.6.2 Liquid Chromatography; 3.6.2.1 HILIC Analysis; 3.6.2.2 Reversed Phase (RP) and Porous Graphitic Carbon (PGC) Chromatography; 3.6.2.3 Weak Anion Exchange (WAX) HPLC Analysis; 3.6.2.4 High pH Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD); 3.6.3 Capillary Electrophoresis (CE); 3.6.4 Fluorophore-assisted Carbohydrate Electrophoresis (FACE) and CGE-LIF; 3.6.5 Mass Spectrometry (MS); 3.6.5.1 Ionization; 3.6.5.2 Derivatization Techniques Used for MS Analysis of Glycans; 3.6.5.3 Fragmentation of Carbohydrates; 3.7 Conclusion; References
505 8 _aPart II BioreactorsChapter 4 Bioreactors for Stem Cell and Mammalian Cell Cultivation; 4.1 Overview of (Mammalian and Stem) Cell Culture Engineering; 4.1.1 Cell Products for Therapeutics; 4.1.2 Cell as a Product: Stem Cells; 4.2 Bioprocess Characterization; 4.2.1 Cell Cultivation Methods; 4.2.2 Cell Metabolism; 4.2.3 Culture Medium Design; 4.2.4 Culture Parameters; 4.2.5 Culture Modes; 4.3 Cell Culture Systems; 4.3.1 Static Culture Systems; 4.3.2 Roller Bottles; 4.3.3 Spinner Flask; 4.3.4 Airlift Bioreactor; 4.3.5 Fixed/Fluidized-Bed Bioreactor; 4.3.6 Wave Bioreactor
650 7 _aMEDICAL / Pharmacology.
_2bisacsh
650 0 _aPharmaceutical biotechnology industry.
650 0 _aBiotechnological process monitoring.
650 7 _aBiotechnological process monitoring.
_2fast
_0(OCoLC)fst00832727
650 7 _aPharmaceutical biotechnology industry.
_2fast
_0(OCoLC)fst01060113
650 1 2 _aBiological Products
_xchemistry.
650 2 2 _aDrug Compounding.
650 2 2 _aTechnology, Pharmaceutical.
650 2 2 _aBioreactors.
655 4 _aElectronic books.
700 1 _aKomives, Claire,
_eeditor.
700 1 _aZhou, Weichang,
_d1963-
_eeditor.
776 0 8 _iPrint version:
_tBioprocessing technology for production of biopharmaceuticals and bioproducts.
_bFirst edition.
_dHoboken, NJ : John Wiley & Sons, Inc., 2018
_z9781118361986
_w(DLC) 2018036496
830 0 _aWiley series in biotechnology and bioengineering.
856 4 0 _uhttps://doi.org/10.1002/9781119378341
_zWiley Online Library
994 _aC0
_bDG1
942 _cEB
999 _c311684
_d311684