TY  - BOOK
AU  - Tegos,A.
AU  - Mylonakis,E.
TI  - Antimicrobial drug discovery: emerging strategies
T2  - Advances in Molecular and Cellular Microbiology
SN  - 9781780640310
PY  - 2012///
CY  - Wallingford           UK
PB  - CABI
KW  - carbon nanotubes
KW  - eukaryotes
KW  - drug development
KW  - biofilms
KW  - antibiotics
KW  - bacterium
KW  - bacterioses
KW  - lipopolysaccharides
KW  - quorum sensing
KW  - fungistats
KW  - infections
KW  - prokaryotes
KW  - Bacteria
KW  - nanotubes
KW  - drug targets
KW  - drug resistance
KW  - phototherapy
KW  - antifungal agents
KW  - peptide antibiotics
KW  - bacterial diseases
KW  - animal models
KW  - photochemotherapy
KW  - efflux pumps
KW  - fungus
KW  - nanotechnology
KW  - disease models
KW  - structure activity relationships
KW  - laboratory animals
KW  - human diseases
KW  - acetyl-CoA carboxylase
KW  - nanomaterials
KW  - mycoses
KW  - antibacterial agents
KW  - bacterial infections
KW  - fungicides
KW  - drug susceptibility
KW  - resistance mechanisms
KW  - fungi
KW  - lysostaphin
N2  - Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies
UR  - https://www.cabidigitallibrary.org/action/showBook?doi=10.1079%2F9781845939434.0000
ER  -