TY - BOOK AU - Halperin,J.J. TI - Lyme disease: an evidence-based approach T2 - CABI Books SN - 9781786392084 PY - 2018/// CY - Wallingford UK PB - CAB International KW - eukaryotes KW - tickborne diseases KW - clinical aspects KW - Lyme disease KW - prokaryotes KW - immunity reactions KW - epidemiology KW - Borrelia miyamotoi KW - Borrelia mayonii KW - Borrelia KW - Spirochaetales KW - lyme borreliosis KW - biochemical genetics KW - man KW - Borrelia burgdorferi KW - tick-borne diseases KW - neuroborreliosis KW - Homo KW - complications KW - molecular genetics KW - arthropods KW - antibacterial agents KW - antibiotics KW - spirochaetosis KW - prognosis KW - symptoms KW - diagnostic techniques KW - animals KW - chronic infections KW - Spirochaetes KW - Bacteria KW - chronic course KW - bacterioses KW - vertebrates KW - Chordata KW - Spirochaetaceae KW - Arachnida KW - immunological reactions KW - mammals KW - microbial ecology KW - disease progression KW - molecular biology KW - chemotherapy KW - vectors KW - aetiology KW - pathogenesis KW - immunity KW - drug therapy KW - causal agents KW - Borrelia bavariensis KW - bacterial infections KW - Acari KW - Ixodes KW - etiology KW - primates KW - Borrelia afzelii KW - clinical picture KW - bacterium KW - Borrelia garinii KW - Hominidae KW - Ixodidae KW - diagnosis KW - Metastigmata KW - invertebrates KW - human diseases KW - immune response KW - disease vectors KW - ticks KW - bacterial diseases KW - disease course N2 - This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects.This new edition: Includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection.As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease UR - https://doi.org/10.1079/9781786392077.0000 UR - https://www.cabidigitallibrary.org/action/showBook?doi=10.1079%2F9781786392077.0000 ER -