This book includes 19 chapters and shows how the challenge of tuberculosis is currently being met, providing insights into the evidence base underlying developments in laboratory diagnosis and techniques, drug development and treatment, as well as measurement of drug resistance and development of vaccines.

Includes bibliographical references and index.

Introduction / Timothy McHugh -- Improving upon sputum smear microscopy for diagnosis of tuberculosis in resource-poor settings / Andrew Ramsay, Karen R Steingart, and Madhukar Pai -- Molecular diagnosis of active pulmonary tuberculosis / Anna Bateson, Kate Reddington, and Justin O'Grady -- Improving on the LJ slope : automated liquid culture / Miguel Viveiros, Diana Machado, Isabel Couto and Leonard Amaral -- Interferon gamma release assays in the diagnosis of latent tuberculosis infection / Ajit Lalvani, Manish Pareek -- Measuring TB immune responses in the lung : the correct target? / Ronan Breen, Marc Lipman -- Sniffing out TB / Ruth McNerney, Claire Turner -- Role of phenotypic methods for drug susceptibility testing of M. tuberculosis isolates in the era of MDR and XDR epidemics / Leonid Heifets -- Genotypic measures of antibiotic susceptibility / Vanessa Mathys, Barun Mathema, and Pablo Bifani -- Molecular tools for fast identification of resistance and characterization of MDR/XDR-TB / Dick van Soolingen -- Monitoring therapy by bacterial load / Denise M. O'Sullivan -- Modelling responses to tuberculosis treatment / G. R. Davies -- Measuring gene expression by quantitative PCR (qPCR) / Isobella Honeyborne -- Transcriptomic approaches to mapping responses to drug therapy for tuberculosis / Simon J. Waddell, Philip D. Butcher -- Mycobacterial lipid bodies and resuscitation-promoting factor dependency as potential biomarkers of response to chemotherapy / N. J. Garton, G. V. Mukamoloval, and M. R. Barer -- Clinical trials in tuberculosis chemotherapy : the challenges / Stephen H. Gillespie -- The identification of 2-aminothiazole-4-carboxylates (ATCs) as a new class of TB agent : a lesson in HIT identification / Geoff Coxon -- Rifamycins revisited / Martin J. Boeree -- Therapy of the XDR-TB patients with thioridazine :an old drug with new applications / Leonard Amaral, Marta Martins , Isabel Couto and Miguel Viveiros -- Vaccines for tuberculosis / Helen McShane.

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Title from PDF title page (viewed July 26, 2013).