Quantitative trait loci analysis in animals / Joel Ira Weller (Agricultural Research Organization (A.R.O.), Institute of Animal Sciences, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel).
Material type:
TextPublisher: Wallingford, Oxfordshire, UK : CABI, 2009Copyright date: ©2009Edition: 2nd editionDescription: 1 online resource (xiii, 272 pages) : illustrations, chartsContent type: - text
- computer
- online resource
- Livestock -- Breeding
- Livestock -- Genetics
- Quantitative genetics
- Animal Husbandry and Production, (New March 2000)
- Animal Genetics and Breeding, (New March 2000)
- Mathematics and Statistics
- Molecular Biology and Molecular Genetics, (Discontinued March 2000, Reinstated and Revised June 2002)
- Animal breeding
- Breeding programmes
- Crosses
- Domestic animals
- Experimental design
- Gene mapping
- Genes
- Genetic markers
- Genetic polymorphism
- Genomes
- Inbred lines
- Inbreeding
- Introgression
- Linkage disequilibrium
- Livestock
- Mathematical models
- Methodology
- Quantitative trait loci
- Quantitative traits
- Selection
- Selection index
- Simulation models
- Traits
- LL180
- LL240
- ZZ100
- ZZ360
- 636.08/21 23
- SF105 .W36 2009eb
This book aims to summarize the scientific literature on methods for quantitative trait loci (QTL) detection and analysis and marker assisted selection (MAS), especially that pertaining to agricultural animal species, emphasizing the special problems associated with animal breeding. The 17 chapters cover the history of QTL and MAS estimation, principles of parameter estimation, mixed model analysis of random and fixed effects, generation of linkage disequilibrium, QTL parameter estimation for crosses between inbred lines, advanced statistical methods for QTL detection and parameter estimation, analysis of QTL as random effects, statistical power to detect QTL, optimization of experimental designs, fine mapping of QTL, complete genome QTL scans, multitrait QTL analysis, determination of genetic polymorphism, principles of selection index and traditional breeding programmes, theory of MAS, current status and simulation studies of MAS and marker-assisted introgression. The information in this book can be applied to actual animal breeding programmes.
Includes bibliographical references (pages 244-257) and indexes.
Historical Overview -- Principles of Parameter Estimation -- Random and Fixed Effects, the Mixed Model -- Experimental Designs to Detect QTL: Generation of Linkage Disequilibrium -- QTL Parameter Estimation for Crosses between Inbred Lines -- Advanced Statistical Methods for QTL Detection and Parameter Estimation -- Analysis of QTL as Random Effects -- Statistical Power to Detect QTL, and Parameter Confidence Intervals -- Optimization of Experimental Designs -- Fine Mapping of QTL -- Complete Genome QTL Scans: The Problem of Multiple Comparisons -- Multitrait QTL Analysis -- From the QTL to the Gene -- Principles of Selection Index and Traditional Breeding Programmes -- Marker-assisted Selection: Theory -- Marker-assisted Selection: Current Status and Results of Simulation Studies -- Marker-assisted Introgression.
Access limited to subscribing institution.
Also available in print format.
Title from PDF title page (viewed July 22, 2015).
There are no comments on this title.