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Macrocyclic lactones in antiparasitic therapy / edited by J. Vercruysse, Faculty of Veterinary Medicine, Department of Virology, Parasitology, Immunology, Ghent University, Belgium and R.S. Rew, Pfizer Animal Health, Exton, Pennsylvania, USA.

Contributor(s): Material type: TextTextPublisher: Wallingford, Oxfordshire, UK : CABI, 2002Copyright date: 2002Description: 1 online resource (xiv, 432 pages) : illustrations, chartsContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
Subject(s): Genre/Form: Additional physical formats: Print version:: Macrocyclic lactones in antiparasitic therapy.DDC classification:
  • 616.9/6061 23
LOC classification:
  • RM412 .M33 2002eb
Online resources: Also available in print format.
Contents:
Chemistry, Pharmacology and Safety of the Macrocyclic Lactones -- Ivermectin, Abamectin and Eprinomectin / W. Shoop and M. Soll -- Doramectin and Selamectin / G.A. Conder and W.J. Baker -- Milbemycin Oxime / M. Jung, A. Saito, G. Buescher, M. Maurer and J.-F. Graf -- Moxidectin / D.W. Rock, R.L. DeLay and M.J. Gliddon -- Pharmacokinetics of the Macrocyclic Lactones : Conventional Wisdom and New Paradigms / D.R. Hennessy and M.R. Alvinerie -- Mode of Action of the Macrocyclic Lactones / R.J. Martin, A.P. Robertson and A.J. Wolstenholme -- Ecological Impact of Macrocyclic Lactones on Dung Fauna / J.W. Steel and K.G. Wardhaugh -- Resistance Against Macrocyclic Lactones / R.K. Prichard -- The Use of Macrocyclic Lactones to Control Parasites of Cattle -- General Efficacy of the Macrocyclic Lactones to Control Parasites of Cattle / J. Vercruysse and R. Rew -- Use of Macrocyclic Lactones to Control Cattle Parasites in Europe / J. Vercruysse and R. Rew -- Use of Macrocyclic Lactones to Control Cattle Parasites in the USA and Canada / R. Rew and J. Vercruysse -- Use of Macrocyclic Lactones to Control Cattle Parasites in South America / C. Eddi, A. Nari and J. Caracostantogolo -- Use of Macrocyclic Lactones to Control Cattle Parasites in Australia and New Zealand / P.A. Holdsworth -- The Use of Macrocyclic Lactones to Control Parasites of Sheep and Goats / R.L. Coop, I. Barger and F. Jackson -- The Use of Macrocyclic Lactones to Control Parasites of Horses / C.M. Monahan and T.R. Klei -- The Use of Macrocyclic Lactones to Control Parasites of Pigs / J. Arends and J. Vercruysse -- The Use of Macrocyclic Lactones in the Control and Prevention of Heartworm and Other Parasites in Dogs and Cats / J. Guerrero, J.W. McCall and C. Genchi -- The Use of Macrocyclic Lactones to Control Parasites of Domesticated Wild Ruminants / S.E. Marley and G.A. Conder -- The Use of Macrocyclic Lactones to Control Parasites of Exotic Pets / S.E. Little, C.B. Greenacre and R.M. Kaplan -- The Use of Macrocyclic Lactones to Control Parasites of Humans / K.R. Brown -- Macrocyclic Lactones as Antiparasitic Agents in the Future / T.G. Geary.
Abstract: This book contains 14 chapters on macrocyclic lactones (MLs). Chapter 1 covers chemistry, pharmacology and drug safety and chapter 2 deals with pharmacokinetics. New information on the mode of action emphasizing glutamate-gated chloride ion channels are reviewed in chapter 3. The impact of MLs on dung fauna is described in chapter 4. Chapter 5 reviews resistance mechanisms and field resistance. The use of MLs to control parasites of cattle is discussed in several sections in chapter 6. The next seven chapters deal with ML use in sheep and goats, horses, pigs, dogs and cats, wild ruminants, exotic pets and man, respectively. Finally, chapter 14 examines scientific, social, political and economic issues that control the future of MLs. The likely readership is composed of researchers and veterinarians.
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This book contains 14 chapters on macrocyclic lactones (MLs). Chapter 1 covers chemistry, pharmacology and drug safety and chapter 2 deals with pharmacokinetics. New information on the mode of action emphasizing glutamate-gated chloride ion channels are reviewed in chapter 3. The impact of MLs on dung fauna is described in chapter 4. Chapter 5 reviews resistance mechanisms and field resistance. The use of MLs to control parasites of cattle is discussed in several sections in chapter 6. The next seven chapters deal with ML use in sheep and goats, horses, pigs, dogs and cats, wild ruminants, exotic pets and man, respectively. Finally, chapter 14 examines scientific, social, political and economic issues that control the future of MLs. The likely readership is composed of researchers and veterinarians.

Includes bibliographical references and index.

Chemistry, Pharmacology and Safety of the Macrocyclic Lactones -- Ivermectin, Abamectin and Eprinomectin / W. Shoop and M. Soll -- Doramectin and Selamectin / G.A. Conder and W.J. Baker -- Milbemycin Oxime / M. Jung, A. Saito, G. Buescher, M. Maurer and J.-F. Graf -- Moxidectin / D.W. Rock, R.L. DeLay and M.J. Gliddon -- Pharmacokinetics of the Macrocyclic Lactones : Conventional Wisdom and New Paradigms / D.R. Hennessy and M.R. Alvinerie -- Mode of Action of the Macrocyclic Lactones / R.J. Martin, A.P. Robertson and A.J. Wolstenholme -- Ecological Impact of Macrocyclic Lactones on Dung Fauna / J.W. Steel and K.G. Wardhaugh -- Resistance Against Macrocyclic Lactones / R.K. Prichard -- The Use of Macrocyclic Lactones to Control Parasites of Cattle -- General Efficacy of the Macrocyclic Lactones to Control Parasites of Cattle / J. Vercruysse and R. Rew -- Use of Macrocyclic Lactones to Control Cattle Parasites in Europe / J. Vercruysse and R. Rew -- Use of Macrocyclic Lactones to Control Cattle Parasites in the USA and Canada / R. Rew and J. Vercruysse -- Use of Macrocyclic Lactones to Control Cattle Parasites in South America / C. Eddi, A. Nari and J. Caracostantogolo -- Use of Macrocyclic Lactones to Control Cattle Parasites in Australia and New Zealand / P.A. Holdsworth -- The Use of Macrocyclic Lactones to Control Parasites of Sheep and Goats / R.L. Coop, I. Barger and F. Jackson -- The Use of Macrocyclic Lactones to Control Parasites of Horses / C.M. Monahan and T.R. Klei -- The Use of Macrocyclic Lactones to Control Parasites of Pigs / J. Arends and J. Vercruysse -- The Use of Macrocyclic Lactones in the Control and Prevention of Heartworm and Other Parasites in Dogs and Cats / J. Guerrero, J.W. McCall and C. Genchi -- The Use of Macrocyclic Lactones to Control Parasites of Domesticated Wild Ruminants / S.E. Marley and G.A. Conder -- The Use of Macrocyclic Lactones to Control Parasites of Exotic Pets / S.E. Little, C.B. Greenacre and R.M. Kaplan -- The Use of Macrocyclic Lactones to Control Parasites of Humans / K.R. Brown -- Macrocyclic Lactones as Antiparasitic Agents in the Future / T.G. Geary.

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