Peptides in energy balance and obesity /
Peptides in energy balance and obesity /
Peptides in energy balance & obesity
edited by Gema Frühbeck, Department of Endocrinology, Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra and CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
- 1 online resource (xii, 389 pages) : illustrations, charts.
- Frontiers in nutritional science ; no. 4 .
- Frontiers in nutritional science ; no. 4. .
Includes bibliographical references and index.
Orexigenic peptides / M.J. Morris and M.J. Hansen -- Anorexigenic peptides / S. Perboni, N. Ueno, G. Mantovani and A. Inui -- Newcomers and supporting actors / J.A. Harrold and G. Williams -- The gut as a second brain / C.J. Small, K. Wynne, and S.R. Bloom -- Elements of the adipostat / H. Hauner -- Natriuretic peptides and other lipolytic peptides involved in the control of lipid mobilization in humans / M. Lafontan, C. Sengenes, C. Moro, J. Galitzky and M. Berlan -- The adipo-hepato-insular axis in glucose homeostasis / J. Gómez-Ambrosi, V. Catalán, and G. Frühbeck -- Adipokines in the immune-stress response / R. Madani, N.C. Ogston, and V. Mohamed-Ali -- Peptides involved in vascular homeostasis / A. Rodríguez and G. Frühbeck -- Hierarchy of neural pathways controlling energy homeostasis / A. Abizaid and T.L. Horvath -- Energy regulatory signals and food reward / D. Figlewicz Lattemann, N.M. Sanders, and A.J. Sipols -- Embracing complexity : the emergence of functional neuroimaging and other methodologies to study the role of the human brain in the pathophysiology of obesity / P.A. Tataranni, N. Pannacciulli, D.S.NT Le and A. Del Parigi -- Overview of the integrative physiology of adipose tissue in energy homeostasis / I. Dugail and M. Guerre-Millo -- Application of 'OMIC' strategies to obesity research / C. Henegar, S. Taleb, D. Langin, J.-D. Zucker and K. Clément -- Implications for the future of obesity management / G.N. Chaldakov, A.B. Tonchev, M. Fiore, M.G. Hristova, R. Pancheva, G. Rancic and L. Aloe.
Access limited to subscribing institution.
The aim of this book is to provide an updated, detailed and comprehensive account of the field through a cutting-edge analysis by leading experts in the area. To achieve this, the book is divided into three parts, focusing on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part I contains three chapters covering the central pathways involved in the control of food intake. The first of these is devoted to the orexigenic neuropeptides, i.e. those that increase or stimulate appetite, while the second is a description of the peptides with anorexigenic effects, i.e. those that decrease or stop food intake. Since this is a rapidly evolving field, the third chapter concentrates on emerging and newly identified factors and their interaction with the already well-known peptides. Part II encompasses six chapters that deal with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. The underlying molecular mechanisms by which adipose tissue enlargement and the subsequent increase in adipokines contribute to the pathophysiological events in the gastrointestinal, hepatic, pancreatic, musculoskeletal, cardiovascular and immune systems are now beginning to be better understood and are covered in detail in this section of the book. Part III contains six chapters providing an integrative approach to current knowledge in energy balance regulation. Adipose tissue biology and the hierarchy of the neural circuitry controlling energy homeostasis deserve special attention, as does the relevance of food reward signals and the links between the homeostatic and hedonic systems. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management.
Obesity--Pathophysiology.
Peptides--metabolism.
Energy Metabolism--physiology.
Obesity--physiopathology.
Energy metabolism.
Homeostasis.
Appetite Regulation.
Peptide hormones.
Physiology of Human Nutrition.
Nutrition related Disorders and Therapeutic Nutrition.
Man.
Adipose tissue.
Anorexiants.
Appetite.
Body weight.
Cardiovascular system.
Digestive system.
Energy.
Energy balance.
Energy expenditure.
Food intake.
Homeostasis.
Hypothalamus.
Immune system.
Liver.
Musculoskeletal system.
Neuropeptides.
Obesity.
Pancreas.
Peptides.
Physiopathology.
Regulation.
Therapy.
Vascular system.
Electronic books.
QP572.P4 / .P47 2009eb
612.4/05
Includes bibliographical references and index.
Orexigenic peptides / M.J. Morris and M.J. Hansen -- Anorexigenic peptides / S. Perboni, N. Ueno, G. Mantovani and A. Inui -- Newcomers and supporting actors / J.A. Harrold and G. Williams -- The gut as a second brain / C.J. Small, K. Wynne, and S.R. Bloom -- Elements of the adipostat / H. Hauner -- Natriuretic peptides and other lipolytic peptides involved in the control of lipid mobilization in humans / M. Lafontan, C. Sengenes, C. Moro, J. Galitzky and M. Berlan -- The adipo-hepato-insular axis in glucose homeostasis / J. Gómez-Ambrosi, V. Catalán, and G. Frühbeck -- Adipokines in the immune-stress response / R. Madani, N.C. Ogston, and V. Mohamed-Ali -- Peptides involved in vascular homeostasis / A. Rodríguez and G. Frühbeck -- Hierarchy of neural pathways controlling energy homeostasis / A. Abizaid and T.L. Horvath -- Energy regulatory signals and food reward / D. Figlewicz Lattemann, N.M. Sanders, and A.J. Sipols -- Embracing complexity : the emergence of functional neuroimaging and other methodologies to study the role of the human brain in the pathophysiology of obesity / P.A. Tataranni, N. Pannacciulli, D.S.NT Le and A. Del Parigi -- Overview of the integrative physiology of adipose tissue in energy homeostasis / I. Dugail and M. Guerre-Millo -- Application of 'OMIC' strategies to obesity research / C. Henegar, S. Taleb, D. Langin, J.-D. Zucker and K. Clément -- Implications for the future of obesity management / G.N. Chaldakov, A.B. Tonchev, M. Fiore, M.G. Hristova, R. Pancheva, G. Rancic and L. Aloe.
Access limited to subscribing institution.
The aim of this book is to provide an updated, detailed and comprehensive account of the field through a cutting-edge analysis by leading experts in the area. To achieve this, the book is divided into three parts, focusing on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part I contains three chapters covering the central pathways involved in the control of food intake. The first of these is devoted to the orexigenic neuropeptides, i.e. those that increase or stimulate appetite, while the second is a description of the peptides with anorexigenic effects, i.e. those that decrease or stop food intake. Since this is a rapidly evolving field, the third chapter concentrates on emerging and newly identified factors and their interaction with the already well-known peptides. Part II encompasses six chapters that deal with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. The underlying molecular mechanisms by which adipose tissue enlargement and the subsequent increase in adipokines contribute to the pathophysiological events in the gastrointestinal, hepatic, pancreatic, musculoskeletal, cardiovascular and immune systems are now beginning to be better understood and are covered in detail in this section of the book. Part III contains six chapters providing an integrative approach to current knowledge in energy balance regulation. Adipose tissue biology and the hierarchy of the neural circuitry controlling energy homeostasis deserve special attention, as does the relevance of food reward signals and the links between the homeostatic and hedonic systems. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management.
Obesity--Pathophysiology.
Peptides--metabolism.
Energy Metabolism--physiology.
Obesity--physiopathology.
Energy metabolism.
Homeostasis.
Appetite Regulation.
Peptide hormones.
Physiology of Human Nutrition.
Nutrition related Disorders and Therapeutic Nutrition.
Man.
Adipose tissue.
Anorexiants.
Appetite.
Body weight.
Cardiovascular system.
Digestive system.
Energy.
Energy balance.
Energy expenditure.
Food intake.
Homeostasis.
Hypothalamus.
Immune system.
Liver.
Musculoskeletal system.
Neuropeptides.
Obesity.
Pancreas.
Peptides.
Physiopathology.
Regulation.
Therapy.
Vascular system.
Electronic books.
QP572.P4 / .P47 2009eb
612.4/05