Nutrigenomics and proteomics in health and disease :
Nutrigenomics and proteomics in health and disease : towards a systems-level understanding of gene-diet interactions /
edited by Martin Kussmann, Lausanne, Switzerland, Patrick Stover, Ithaca, NY, US.
- Second edition.
- 1 online resource.
- Hui: food science and technology Functional food science and technology series .
- Functional food science and technology series. .
Revision of: Nutrigenomics and proteomics in health and disease / editors, Yoshinori Mine, Kazuo Miyashita, Fereidoon Shahidi.
Includes bibliographical references and index.
Title Page ; Copyright Page; Contents; Contributors; Preface; Biography of Martin Kussmann; Section I Genes, Proteins, and Nutrition ; Chapter 1 The use of transcriptomics as a tool to identify differences in the response to diet; 1.1 New concepts in nutrition research; 1.2 Comprehensive phenotyping; 1.3 Phenotypic flexibility; 1.4 Factors that influence the transcriptome response to diet; 1.5 Using transcriptomics to explain the mechanism behind differences in response to diet; 1.6 Conclusion; 1.7 Future perspectives; References Chapter 2 Genetic or nutritional disturbances in folate-related pathways and epigenetic interactions 2.1 Introduction; 2.2 Nutrition and one-carbon metabolism ; 2.3 Importance of DNA methylation at CpG dinucleotides; 2.4 Folate-dependent disorders: Dietary impact ; 2.5 Genetic influences on phenotype and interactions with epigenetics; 2.6 Epigenetic inheritance across generations; 2.7 Conclusions; References; Chapter 3 Early-life development and epigenetic mechanisms: Mediators of metabolic programming and obesity risk ; 3.1 Introduction; 3.2 Origins of DOHaD and its conceptual basis 3.3 Epigenetic mechanisms3.4 Early-life nutrition, epigenetics, and metabolic programming ; 3.5 Paternal effects; 3.6 Transgenerational epigenetic inheritance; 3.7 The potential value of DOHaD principles and epigenetic biology to the improvement of human health; 3.8 Conclusion; Acknowledgments; References; Section II Bioactives and Phytonutrients ; Chapter 4 Bioactive interactions in food and natural extracts; 4.1 Natural compounds as all compounds produced by nature; 4.2 Not all natural compounds are created active; 4.3 On the road of modern technologies for bioactive discovery 4.4 Metabolomics strategies applied to bioactives biochemistry4.5 Bioactives as multi‐target network instigators; 4.6 'Let food be thy medicine and medicine be thy food' - outlook; Acknowledgments; References; Chapter 5 Anthocyanins in metabolic health and disease; 5.1 Introduction; 5.2 Chemical structure; 5.3 Structural effects on stability; 5.4 Systemic bioavailability and tissue distribution; 5.5 Metabolism and nutrigenomic effects; 5.6 Conclusions; Acknowledgments; References; Chapter 6 Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis; 6.1 Introduction 6.2 Dietary vitamins E and C and CVD6.3 Dietary polyphenols and CVD; 6.4 Flavonoids and angiogenesis; 6.5 Conclusion; Acknowledgments; References; Chapter 7 Genomics and proteomics approaches to identify resveratrol targets in cancer; 7.1 Introduction; 7.2 Sources and health benefits of resveratrol; 7.3 Resveratrol for cancer prevention and therapy; 7.4 Functional genomics approaches to identify resveratrol targets in cancer; 7.5 Proteomics approaches to identify resveratrol targets in cancer; 7.6 Metabolomics approaches to identify pathways modified by resveratrol in cancer
"This volume brings together leading experts in the areas of nutrition, nutrigenomics, metabolic programming, food-based bioactive dietary components and the gut microbiome, as well as those expert in the application of innovative tools and methods for statistical and biological network analysis, which are now at the forefront of nutritional and biomedical sciences. The articles provide a roadmap for the integration of normative science methods and approaches with more comprehensive systems biology-based investigations that deploy a multitude of omic platforms. This integration is essential to escape the bottleneck in knowledge generation by applying decades of knowledge of nutrients and their function to comprehensive omics and clinical data acquisition, processing, visualization, and interpretation. Achieving a systems-level understanding of nutrient function in health and disease will usher in an age of precision nutrition in support of maximizing human health and potential"--
9781119101277 1119101271 9781119101253 1119101255
2017009533
Nutrition--Genetic aspects.
TECHNOLOGY & ENGINEERING--Food Science.
MEDICAL / Physiology
SCIENCE / Life Sciences / Human Anatomy & Physiology
Nutrition--Genetic aspects.
Electronic books.
QP144.G45
612.3
Revision of: Nutrigenomics and proteomics in health and disease / editors, Yoshinori Mine, Kazuo Miyashita, Fereidoon Shahidi.
Includes bibliographical references and index.
Title Page ; Copyright Page; Contents; Contributors; Preface; Biography of Martin Kussmann; Section I Genes, Proteins, and Nutrition ; Chapter 1 The use of transcriptomics as a tool to identify differences in the response to diet; 1.1 New concepts in nutrition research; 1.2 Comprehensive phenotyping; 1.3 Phenotypic flexibility; 1.4 Factors that influence the transcriptome response to diet; 1.5 Using transcriptomics to explain the mechanism behind differences in response to diet; 1.6 Conclusion; 1.7 Future perspectives; References Chapter 2 Genetic or nutritional disturbances in folate-related pathways and epigenetic interactions 2.1 Introduction; 2.2 Nutrition and one-carbon metabolism ; 2.3 Importance of DNA methylation at CpG dinucleotides; 2.4 Folate-dependent disorders: Dietary impact ; 2.5 Genetic influences on phenotype and interactions with epigenetics; 2.6 Epigenetic inheritance across generations; 2.7 Conclusions; References; Chapter 3 Early-life development and epigenetic mechanisms: Mediators of metabolic programming and obesity risk ; 3.1 Introduction; 3.2 Origins of DOHaD and its conceptual basis 3.3 Epigenetic mechanisms3.4 Early-life nutrition, epigenetics, and metabolic programming ; 3.5 Paternal effects; 3.6 Transgenerational epigenetic inheritance; 3.7 The potential value of DOHaD principles and epigenetic biology to the improvement of human health; 3.8 Conclusion; Acknowledgments; References; Section II Bioactives and Phytonutrients ; Chapter 4 Bioactive interactions in food and natural extracts; 4.1 Natural compounds as all compounds produced by nature; 4.2 Not all natural compounds are created active; 4.3 On the road of modern technologies for bioactive discovery 4.4 Metabolomics strategies applied to bioactives biochemistry4.5 Bioactives as multi‐target network instigators; 4.6 'Let food be thy medicine and medicine be thy food' - outlook; Acknowledgments; References; Chapter 5 Anthocyanins in metabolic health and disease; 5.1 Introduction; 5.2 Chemical structure; 5.3 Structural effects on stability; 5.4 Systemic bioavailability and tissue distribution; 5.5 Metabolism and nutrigenomic effects; 5.6 Conclusions; Acknowledgments; References; Chapter 6 Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis; 6.1 Introduction 6.2 Dietary vitamins E and C and CVD6.3 Dietary polyphenols and CVD; 6.4 Flavonoids and angiogenesis; 6.5 Conclusion; Acknowledgments; References; Chapter 7 Genomics and proteomics approaches to identify resveratrol targets in cancer; 7.1 Introduction; 7.2 Sources and health benefits of resveratrol; 7.3 Resveratrol for cancer prevention and therapy; 7.4 Functional genomics approaches to identify resveratrol targets in cancer; 7.5 Proteomics approaches to identify resveratrol targets in cancer; 7.6 Metabolomics approaches to identify pathways modified by resveratrol in cancer
"This volume brings together leading experts in the areas of nutrition, nutrigenomics, metabolic programming, food-based bioactive dietary components and the gut microbiome, as well as those expert in the application of innovative tools and methods for statistical and biological network analysis, which are now at the forefront of nutritional and biomedical sciences. The articles provide a roadmap for the integration of normative science methods and approaches with more comprehensive systems biology-based investigations that deploy a multitude of omic platforms. This integration is essential to escape the bottleneck in knowledge generation by applying decades of knowledge of nutrients and their function to comprehensive omics and clinical data acquisition, processing, visualization, and interpretation. Achieving a systems-level understanding of nutrient function in health and disease will usher in an age of precision nutrition in support of maximizing human health and potential"--
9781119101277 1119101271 9781119101253 1119101255
2017009533
Nutrition--Genetic aspects.
TECHNOLOGY & ENGINEERING--Food Science.
MEDICAL / Physiology
SCIENCE / Life Sciences / Human Anatomy & Physiology
Nutrition--Genetic aspects.
Electronic books.
QP144.G45
612.3